Streptococcus pneumoniae: virulence factors and variation
نویسندگان
چکیده
منابع مشابه
Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccines.
Although pneumococcal conjugate vaccines are close to being licensed, a more profound knowledge of the virulence factors responsible for the morbidity and mortality caused by Streptococcus pneumoniae is necessary. This review deals with the major structures of pneumococci involved in the pathogenesis of pneumococcal disease and their interference with the defense mechanisms of the host. It is w...
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Streptococcus pneumoniae is one of the major human bacterial pathogens. Current prophylactic agents against this pathogen are limited in their protective abilities and the role of therapeutics has been inadequate as resistant strains emerge. The development of new and improved therapies to combat the pneumococcal disease is necessary. In order to accomplish this, an understanding of the interac...
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The morbidity and mortality rates associated with Streptococcus pneumoniae remain very high worldwide. The virulence of this bacterium is largely dependent on its polysaccharide capsule, which is quite heterogeneous and represents a serious obstacle for designing effective vaccines. However, it has been demonstrated that numerous protein virulence factors are involved in the pathogenesis of pne...
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The polysaccharide capsule is the major virulence factor of Streptococcus pneumoniae (pneumococcus), a major human pathogen. The sequences in the promoter and coding regions of the capsule gene locus undergo extensive variations through the natural transformation-mediated horizontal gene transfer. The sequence variations in the coding region have led to at least 97 capsular serotypes. However, ...
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The bacterial factors responsible for the variation in invasive potential between different clones and serotypes of Streptococcus pneumoniae are largely unknown. Therefore, the isolation of rare serotype 1 carriage strains in Indigenous Australian communities provided a unique opportunity to compare the genomes of non-invasive and invasive isolates of the same serotype in order to identify such...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2010
ISSN: 1198-743X
DOI: 10.1111/j.1469-0691.2010.03183.x